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Formation
Amides are formed by the dehydration reaction of a carboxylic acid
with an amine. You should recall that esters are formed by the dehydration reaction of a
carboxylic acid with an alcohol. Therefore, the reactions are similar.
| The formation of an amide from a carboxylic acid and ammonia, as shown
here (and in Example 7 in your workbook), is another example of an intermolecular
dehydration reaction. An OH from the acid and an H from the amine are split away from
their compounds to form water. The remainder of the two compounds are joined together by a
covalent bond to form an amide. |
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| The dehydration reaction can occur with an amine instead of ammonia and the
product is still an amide. |
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E-mail instructor:
Kerry Cotter
Clackamas Community College
©2001, 2003 Clackamas Community College, Hal Bender |
![Equation showing the reaction of an acid and amonia to form an amide. [65rxn03.JPG]](images/65rxn03.JPG)
![Equation showing the reaction of an acid and an amine to form an amide. [65rxn04.JPG]](images/65rxn04.JPG)